Advancing Peritoneal Dialysis (PD)
Millions of patients worldwide are dependent on dialysis to survive. There are two types of dialysis (renal replacement therapy): Hemodialysis (mechanical blood purification) and peritoneal dialysis (PD), in which the blood is purified by a PD fluid in the abdomen. Our novel dialysate, PDprotec®, is designed to improve the outcomes of this treatment and reduce the burden of kidney failure for patients and healthcare providers. Zytoprotec expects the number of dialysis patients to increase significantly for many years to come. It is estimated that 90% of dialysis fluids contain sugar. The global market for dialysis fluids was worth more than US$ 3 billion in 2021. It has grown steadily over the last 20+ years and is expected to continue to grow at high rates. A novel PD fluid such as PDprotec® is also expected to accelerate market growth since lesser unwanted side-effects will enable patients to stay longer on PD (automatic market growth). In addition and most importantly, Zytoprotec expects a marked shift from HD to PD with a substantially better product on the market compared to the best products currently available since PD gives patients more freedom, is a more natural form of dialysis than HD, and is substantially cheaper and environmentally more friendly than HD.
PDprotec® – key advantages
Fewer harmful side effects such as peritonitis
Patients can stay on the more pleasant and gentler PD for longer
Therefore, the share of PD in dialysis increases automatically
Presumably cardiovascular protection and thus better survival
Award-winning science
and world-class
clinical research
Science and Technology
The development of PDprotec® has been advanced by Zytoprotec’s own scientists and clinical experts and by the expertise and support provided by global leaders in the field of PD represented in our Scientific Advisory Board.
Scientific Advisory Board
A clear step forward in next generation PD solutions."*
Prof. Dr. Nicholas Topley
They say a bit of stress is good for you – Zytoprotec research shows nicely how you can incorporate this principle into clinical practice of PD."
Prof. Dr. Janusz Witowski
Targeting peritoneal membrane barrier and transport function by PDprotec® improves PD efficacy and biocompatibility and should improve PD substantially and ultimately patient long-term outcome."*
Prof. Dr. Claus Peter Schmitt, Heidelberg
A big step toward the preservation of peritoneal membrane in PD patients. An attractive approach to preserve the peritoneal membrane, complementary to the efforts to improve fluid biocompatibility, is the use of additives protecting the mesothelium. In this context, Zytoprotec, through the wise combination of basic and clinical research, has developed novel PD fluids that mitigate peritoneal damage and, as a consequence, reduce systemic side-effects of dialysis treatment."*
Prof. Dr. Manuel Lopez Cabrera
The phase II data suggest that PDprotec will restore mesothelial integrity and inflammatory responses, providing a potential step change for PD. A sufficiently powered phase 3 study that has impacts on clinically meaningful endpoints is now required.“*
Prof. Dr. Simon Davies, Keele, United Kingdom
*Quote was made in an e-mail correspondence between the expert and Professor Aufricht